Non-nutritive sweeteners (NNS) are a strategy to lower sugar intake, but aspects hamper NNS use. Replacing sugar with NNS will affect taste. There are also discussions around potential health risks. The precise implications of health effects are still unknown, we need more insights into possible health effects. SWEETSPOT is a multi-disciplinary project aiming to enhance understanding of how NNS affect texture and flavor and how the consumption of foods containing NNS might impact health.